No Label? No Problem!
Frederik Großerüschkamp and Klaus Gerwert describe label-free digital pathology for diagnosis and biomarker research
Today, the gold standard for clinical cancer diagnosis is the visual inspection of H&E-labeled tissue thin sections by a pathologist. Coming in at a close second is the immunohistochemical stain. But proper evaluation of these labeled samples depends on the pathologist’s expertise and the reliability and reproducibility of the staining – aspects that may vary from one situation to the next.
To overcome that obstacle, we established a technique for classification of tissue thin sections that is both label-free and inter-/intra-observer-independent. Our infrared (IR) imaging uses spatially resolved infrared spectra as fingerprints for biochemical disease status. The spectra are automatically classified through bioinformatics, eliminating the variability introduced by a subjective observer.
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