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Inside the Lab Analytical science, Clinical care, Microscopy and imaging, Histology, Precision medicine, Microscopy and imaging, Technology and innovation

No Label? No Problem!

Today, the gold standard for clinical cancer diagnosis is the visual inspection of H&E-labeled tissue thin sections by a pathologist. Coming in at a close second is the immunohistochemical stain. But proper evaluation of these labeled samples depends on the pathologist’s expertise and the reliability and reproducibility of the staining – aspects that may vary from one situation to the next.

To overcome that obstacle, we established a technique for classification of tissue thin sections that is both label-free and inter-/intra-observer-independent. Our infrared (IR) imaging uses spatially resolved infrared spectra as fingerprints for biochemical disease status. The spectra are automatically classified through bioinformatics, eliminating the variability introduced by a subjective observer.

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