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Inside the Lab Technology and innovation, Liquid biopsy, Oncology

Inspiring Inventions

Jérôme Galon, Inventor of Immunoscore

Galon’s new assay, winner of this year’s European Inventor Award for Research, seeks to classify cancer patients in routine clinical settings

What inspired the invention of Immunoscore?

I wanted to demonstrate the importance of pre-existing immunity in cancer. At the time, the accepted hallmarks of cancer didn’t even include the possible role of the immune system. We began a massive analysis of immune cells in large cohorts of patients to decipher the immune microenvironment using quantitative assessment of immune subpopulations within tumors – that is, quantifying immune cells using digital pathology and image analysis. We showed the significant contribution of memory T cells to the prevention of early-metastatic dissemination (1), and that numbers of adaptive immune cells were better predictors of the clinical outcomes for colorectal cancer than all traditional histopathological parameters (2). We validated our findings in several further studies (3,4).

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About the Author

Michael Schubert

While obtaining degrees in biology from the University of Alberta and biochemistry from Penn State College of Medicine, I worked as a freelance science and medical writer. I was able to hone my skills in research, presentation and scientific writing by assembling grants and journal articles, speaking at international conferences, and consulting on topics ranging from medical education to comic book science. As much as I’ve enjoyed designing new bacteria and plausible superheroes, though, I’m more pleased than ever to be at Texere, using my writing and editing skills to create great content for a professional audience.

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