Two high-profile innovators describe new diagnostic technologies and the promise they offer for cancer detection and treatment
Michael Schubert | | Longer Read
Jérôme Galon, Inventor of Immunoscore
Galon’s new assay, winner of this year’s European Inventor Award for Research, seeks to classify cancer patients in routine clinical settings
What inspired the invention of Immunoscore?
I wanted to demonstrate the importance of pre-existing immunity in cancer. At the time, the accepted hallmarks of cancer didn’t even include the possible role of the immune system. We began a massive analysis of immune cells in large cohorts of patients to decipher the immune microenvironment using quantitative assessment of immune subpopulations within tumors – that is, quantifying immune cells using digital pathology and image analysis. We showed the significant contribution of memory T cells to the prevention of early-metastatic dissemination (1), and that numbers of adaptive immune cells were better predictors of the clinical outcomes for colorectal cancer than all traditional histopathological parameters (2). We validated our findings in several further studies (3,4).
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