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Inside the Lab Precision medicine, Genetics and epigenetics, Oncology, Guidelines and recommendations

Finding a Cancer Treatment (NCI-)MATCH

In 2015, the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) and the National Cancer Institute (NCI) teamed up to run the largest precision medicine cancer trial to date – the NCI-Molecular Analysis for Therapy Choice (NCI-MATCH). The aim? To test the genetic profile of tumors and match patients to targeted treatments without limiting the trial to one type of cancer or to approved drugs (1).

Before the trial, the frequency of tumor gene abnormalities across cancer types was unknown. But the study found a 37.6 percent chance of a tumor’s having a defect that matches a targeted drug – a rate that the researchers hope will demonstrate to clinicians the value of genetic testing. Match rate varied across cancer types, with rarer cancers matching at higher rates than more common types – highlighting the lack of targeted treatments for mutations within those cancers. It was also common for several tumor gene abnormalities to drive cancer growth simultaneously, suggesting that combination therapies may be effective for many patients.

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About the Author

Olivia Gaskill

During my undergraduate degree in psychology and Master’s in neuroimaging for clinical and cognitive neuroscience, I realized the tasks my classmates found tedious – writing essays, editing, proofreading – were the ones that gave me the greatest satisfaction. I quickly gathered that rambling on about science in the bar wasn’t exactly riveting for my non-scientist friends, so my thoughts turned to a career in science writing. At Texere, I get to craft science into stories, interact with international experts, and engage with readers who love science just as much as I do.

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