Cookies

Like most websites The Pathologist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Inside the Lab Clinical care, Digital and computational pathology, Oncology, Microscopy and imaging, Technology and innovation, Screening and monitoring, Precision medicine

Characterizing Cancer

What is the goal of our ongoing quest to discover new biomarkers for cancer therapy? Collectively, we want to improve personalized therapy for our patients. It may sound straightforward, but for oncologists trying to unravel the complexities of patients’ tumors, heterogeneity presents a challenge. Tumor cells often behave differently depending on their location, which means that a single tissue sample may contain several cell types, making interpretation complicated. Worse yet, some cell types may not be present in the sample at all – meaning that a personalized treatment strategy might not tackle a patient’s entire tumor.

Digital spatial profiling (DSP), a novel barcoding approach, aims to address some of these issues by extracting more data from a single tissue sample, potentially overcoming a consistent limiting factor in tumor analysis. “The high plex capabilities of DSP technology enabled us to interrogate many more potential biomarkers than would have been possible on these very small tissue biopsies with standard or multiplexed immunohistochemistry approaches,” says Christian Blank of the Netherlands Cancer Institute. Blank used the technology to investigate how the pre-existing immune status of stage III melanoma predicts treatment response (1).

Read the full article now

Log in or register to read this article in full and gain access to The Pathologist’s entire content archive. It’s FREE and always will be!

Login if you already created an account

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Pathologist magazine
Register

Or Login as a Guest or via Social Media

About the Author

Luke Turner

While completing my undergraduate degree in Biology, I soon discovered that my passion and strength was for writing about science rather than working in the lab. My master’s degree in Science Communication allowed me to develop my science writing skills and I was lucky enough to come to Texere Publishing straight from University. Here I am given the opportunity to write about cutting edge research and engage with leading scientists, while also being part of a fantastic team!

Related Application Note

Inside the Lab Oncology

Oncomine Dx Target Test – an IVD NGS solution for every lab

| Contributed by ThermoFisher Scientific

Newsletter

Send me the latest from The Pathologist.

Sign up now

Register to The Pathologist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Pathologist magazine

Register