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Diagnostics Genetics and epigenetics, Liquid biopsy, Neurology, Screening and monitoring

Uncovering Brain Tumor Biomarkers in Blood and CSF

Credit: Wikimedia user Bobjgalindo.

Although diagnosing brain tumors early is critical for better outcomes, accessing biomarkers in the brain presents unique challenges – a lack of minimally invasive methods, a complex location, and the natural blockade created by the blood-brain barrier, to name a few. Medulloblastomas and gliomas are the most common brain tumors in children and adults, respectively. Genomic characterization of medulloblastomas may lead to more precise molecular diagnoses – but biopsies are risky and may not accurately represent the tumor.

Analyzing circulating tumor DNA (ctDNA) in cerebrospinal fluid (CSF) may offer a route to accurate characterization and diagnosis of pediatric brain tumors. In a proof-of-concept study, researchers at the Vall d’Hebron Institute of Oncology showed that CSF ctDNA holds valuable information about a tumor’s mutations and provides valuable information about prognosis and intratumoral genomic heterogeneity (1).

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About the Author

Olivia Gaskill

During my undergraduate degree in psychology and Master’s in neuroimaging for clinical and cognitive neuroscience, I realized the tasks my classmates found tedious – writing essays, editing, proofreading – were the ones that gave me the greatest satisfaction. I quickly gathered that rambling on about science in the bar wasn’t exactly riveting for my non-scientist friends, so my thoughts turned to a career in science writing. At Texere, I get to craft science into stories, interact with international experts, and engage with readers who love science just as much as I do.

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