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The Pathologist / Issues / 2023 / Jan / Research Roundup
Endocrinology Genetics and epigenetics Biochemistry and molecular biology Endocrinology Oncology Molecular Pathology

Research Roundup

The latest research in pathology and laboratory medicine – in a succinct and speedy summary

By Georgia Hulme 01/25/2023 News 1 min read

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Stroke stratification
 

A genome-wide association study of 110,182 patients who suffered a stroke has revealed 61 new stroke-risk loci (1). An independent follow-up saw replicated results in 87 percent of primary risk loci and 60 percent of secondary loci. A strong susceptibility to stroke across ancestries was also observed.

Puberty predictor
 

Researchers have discovered that INSL3 – a peptide hormone produced by Leydig cells in the testis – remains biologically consistent throughout puberty, making it a promising biomarker for age-related morbidity (2). The amount of INSL3 in blood samples correlated with a multitude of age-related issues – including diabetes, cardiovascular disease, and sexual dysfunction. 

Not so suPAR
 

A recent study has found that levels of soluble urokinase-type plasminogen activator receptor (suPAR) are 17 percent higher in patients with heart failure (3). Researchers measured suPAR and B-type natriuretic peptide levels in 3,437 patients undergoing coronary angiogram and found suPAR levels to be effective myocardial markers of heart failure.

Credit : Wikimedia Commons

Careful classification
 

To investigate melanoma overdiagnosis, researchers have analyzed cancer registry data on patients diagnosed with stage one lesions less than 1 mm thick (4). Results showed that the overall seven-year mortality from melanoma was 25 percent, but a subset of the same 25 percent had a mortality risk under one percent, signaling a need for clearer classification criteria.

T. rex truths
 

A closer examination of Sue the Tyrannosaurus rex refutes the theory that mandibular lesions were caused by the parasitic protozoan Trichomonas (5). A comparative anatomical study with other Triassic reptiles instead revealed a strong resemblance to healing fractures – possibly caused by a traumatic injury during combat.

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References

    1. A Mishra et al., Nature, 611, 115 (2022). PMID: 36376532.
    2. R Ivell et al., Front Endocrinol, 13 (2022). PMID: 36425465.
    3. SS Hayek et al., J Card Fail (2022). PMID: 36122818.
    4. MM Eguchi et al., Cancer, 129, 89 (2022). PMID: 36336975.
    5. B Rothchild et al., Cretac Rec, 140 (2022).

About the Author(s)

Georgia Hulme

Associate Editor for the Pathologist

More Articles by Georgia Hulme

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