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Diagnostics Genetics and epigenetics, Regulation and standards, Omics

Genotyping Guidance

The Association for Molecular Pathology (AMP) has recently published recommendations outlining cytochrome P450 2C19 (CYP2C19) genotyping. CYP2C19 is involved in the metabolism of many common drugs, which is why AMP’s Pharmacogenetics (PGx) Working Group wanted to define key points for clinical testing. “The purpose of this guideline is to aid clinical lab professionals when designing and validating clinical CYP2C19 genotyping assays, and to promote the standardization of testing across different laboratories,” says Victoria Pratt, first author of the recommendations, Associate Professor of Medical and Molecular Genetics at Indiana University School of Medical, and AMP PGx Working Group Chair. “As with all of our AMP guidelines, we base our recommendations on the evidence that has been published at the time, and what the evidence indicates is necessary to improve professional pharmacogenetics practice and patient care.”

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About the Author

William Aryitey

My fascination with science, gaming, and writing led to my studying biology at university, while simultaneously working as an online games journalist. After university, I travelled across Europe, working on a novel and developing a game, before finding my way to Texere. As Associate Editor, I’m evolving my loves of science and writing, while continuing to pursue my passion for gaming and creative writing in a personal capacity.

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