Using a macro-scanner to image larger samples with the detail of fluorescence microscopy
William Aryitey |
“Fluorescence microscopy is considered a minimally invasive optical technique to address a number of biological questions that cannot be answered by other means in a fast and relatively inexpensive way,” says Vladislav Shcheslavskiy, a senior research scientist at Becker & Hickl. “Although there are a lot of powerful methods to interrogate biological systems in vitro, there are a limited number of ways to explore samples in vivo, especially when they’re large.”
To overcome this difficulty, Shcheslavskiy and colleagues from Russia developed a system that allows users to boost fluorescence laser scanning microscopy to image samples as large as 18 mm² – where the previous limit was less than 1 mm². But what separates this technology from mainstream imaging techniques for large samples?
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