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Diagnostics Analytical science, Liquid biopsy, Precision medicine, Regulation and standards

Diagnostics Everywhere

The precision diagnostic tests that often inform essential treatment decisions can take years to develop and validate – and even then their applicability is often limited to specific indications. Companion diagnostics, for example, are useful for predicting safety- and efficacy-related responses to treatment, but may be considered niche in their window of application. Broader diagnostics that harness the utility of previously validated, well-studied circulating biomarkers can be used to address disease-specific diagnostic and prognostic questions, both in and out of the clinic.

Continuous or semi-continuous biomarker assessment relies on our existing knowledge of changing biomarker concentrations over time and/or in response to disease development. For many clinically established analytes, however, the expected shift in concentration over time is poorly defined, especially in early disease. These days, artificial intelligence can be applied to help pinpoint disease risk and progression from routine lab tests, and – in some cases – routine monitoring can enhance the power of these approaches.

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About the Authors

Kimia Sobhani

Kimia Sobhani is Chief Clinical Chemist and Director of the Core Laboratories at Cedars-Sinai Medical Center, Los Angeles, USA


Jennifer Van Eyk

Jennifer Van Eyk is Director of the Advanced Clinical Biosystems Research Institute at Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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