Diagnostics Histology, Oncology, Clinical care, Microscopy and imaging

Case of the Month

08/18/2017

A well-circumscribed peripheral lung tumor measuring 3 cm in diameter was discovered on a routine X-ray examination of an otherwise healthy 50-year-old man. The tumor was positive for CD34, Bcl-2, CD99, and STAT6, and showed low proliferative activity by MIB1 (Ki-67) immunostaining. Cytogenetic analysis revealed no evidence of X;18 translocation.

What is the most likely diagnosis?

A. Synovial sarcoma

B. Benign fibrous histiocytoma

C. Solitary fibrous tumor

D. Myopericytoma

D. Malignant mesothelioma

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We will reveal the answer in next month’s issue!

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Answer to last month’s Case of the Month…

A. Systemic lupus erythematosus

The light microscopy of this periodic acid-Schiff stained slide shows marked thickening of the capillary loops, colloquially known as “wireloops.” The electron microphotograph shows osmiophilic deposits on the sub-endothelial side of the capillary loop and also in the mesangial area. These findings are diagnostic of lupus nephritis, a common feature of systemic lupus erythematosus.

Submitted by Ivan Damjanov, The University of Kansas, Kansas City, USA.

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