Subscribe to Newsletter
Diagnostics Histology, Training and education

Case of the Month

A 53-year-old man presented with scrotal pain and a 1.5 cm testicular mass. Special stain for mucicarmine was negative. Immunohistochemistry (IHC) was negative for pancytokeratin, CK7, CK20, CDX2, inhibin, OCT-3/4, and chromogranin. What is the most likely diagnosis?

What is your diagnosis?

a. Leydig cell tumor
b. Sertoli cell tumor
c. Metastatic signet ring carcinoma from the colon
d. Primary signet ring stromal tumor of the testis

Click here to register your guess.

We will reveal the answer next month.

Do you have an interesting case that you would like us to feature? Email it to [email protected]

Answer to May’s Case of the Month...

C. Mucoepidermoid carcinoma

This is a Warthin-like variant of mucoepidermoid carcinoma. At low power, the cystic nature of the process and the prominent lymphoid stroma are similar to Warthin’s tumor, but the classic bilayered oncocytic epithelium of that lesion is absent. There is no sebaceous type epithelium present, and the irregular, haphazard nature of the cystic spaces is somewhat unusual for sebaceous adenoma or lymphoepithelial cyst. In difficult cases, diagnosticians can pursue testing for the MAML2 translocation, which is present in mucoepidermoid carcinoma and absent in the other entities.

Submitted by Frank Ingram and Patrick Ware, Presbyterian Pathology Group, North Carolina, USA.

Receive content, products, events as well as relevant industry updates from The Pathologist and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

Register to The Pathologist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Pathologist magazine