Conexiant
Login
  • The Analytical Scientist
  • The Cannabis Scientist
  • The Medicine Maker
  • The Ophthalmologist
  • The Pathologist
  • The Traditional Scientist
The Pathologist
  • Explore Pathology

    Explore

    • Latest
    • Insights
    • Case Studies
    • Opinion & Personal Narratives
    • Research & Innovations
    • Product Profiles

    Featured Topics

    • Molecular Pathology
    • Infectious Disease
    • Digital Pathology

    Issues

    • Latest Issue
    • Archive
  • Subspecialties
    • Oncology
    • Histology
    • Cytology
    • Hematology
    • Endocrinology
    • Neurology
    • Microbiology & Immunology
    • Forensics
    • Pathologists' Assistants
  • Training & Education

    Career Development

    • Professional Development
    • Career Pathways
    • Workforce Trends

    Educational Resources

    • Guidelines & Recommendations
    • App Notes

    Events

    • Webinars
    • Live Events
  • Events
    • Live Events
    • Webinars
  • Profiles & Community

    People & Profiles

    • Power List
    • Voices in the Community
    • Authors & Contributors
  • Multimedia
    • Video
    • Podcasts
Subscribe
Subscribe

False

The Pathologist / Issues / 2020 / Aug / Cancer Drivers in the Dark Genome
Endocrinology Endocrinology Genetics and epigenetics Omics Oncology Molecular Pathology

Cancer Drivers in the Dark Genome

A new tool for identifying cancer driver mutations in noncoding DNA

By Michael Schubert 08/22/2020 Quick Read (pre 2022) 1 min read

Share

Only 2 percent of the human genome encodes proteins; the remaining 98 percent is a mystery – and one we are just beginning to unravel. Evidence increasingly shows that noncoding DNA may be involved in gene regulation, including in cancer formation. But how can we plumb the depths of the noncoding genome? A new computational tool, cis-expression, may offer a solution (1).

Cis-X identifies driver mutations in two steps. First, it seeks out genes expressed on only one chromosome and at abnormally high levels; next, it looks for noncoding DNA alterations in the 3D genome. “Cis-X offers a powerful new approach for investigating the functional role of noncoding variants in cancer, which may expand the scope of precision medicine to treat cancer caused by such variants,” said senior author Jinghui Zhang (2).

The software is available free of charge at: tp.txp.to/ZhangLab/cis-X

Newsletters

Receive the latest pathology news, personalities, education, and career development – weekly to your inbox.

Newsletter Signup Image

References

  1. Y Liu et al., Nat Genet, 52, 811 (2020). PMID: 32632335.
  2. St. Jude Children’s Research Hospital (2020). Available at: https://bit.ly/317hZvh.

About the Author(s)

Michael Schubert

While obtaining degrees in biology from the University of Alberta and biochemistry from Penn State College of Medicine, I worked as a freelance science and medical writer. I was able to hone my skills in research, presentation and scientific writing by assembling grants and journal articles, speaking at international conferences, and consulting on topics ranging from medical education to comic book science. As much as I’ve enjoyed designing new bacteria and plausible superheroes, though, I’m more pleased than ever to be at Texere, using my writing and editing skills to create great content for a professional audience.

More Articles by Michael Schubert

Explore More in Pathology

Dive deeper into the world of pathology. Explore the latest articles, case studies, expert insights, and groundbreaking research.

False

Advertisement

Recommended

False

Related Content

A Unique Perspective
Endocrinology
A Unique Perspective

December 29, 2022

5 min read

Sitting Down With… Sylvia Asa, Consultant in Endocrine Pathology, University Hospitals Cleveland Medical Center and University Health Network (Toronto) and Professor of Pathology, Case Western Reserve University, Cleveland, Ohio, USA

Demystifying Diabetic Neuropathy
Endocrinology
Demystifying Diabetic Neuropathy

January 10, 2023

1 min read

Nerve damage is all too common in type 2 diabetes, but can we predict whether a patient is likely to develop peripheral neuropathy?

Research Roundup
Endocrinology
Research Roundup

January 25, 2023

1 min read

The latest research in pathology and laboratory medicine – in a succinct and speedy summary

Sylvia Asa on Pioneering Digital Pathology
Endocrinology
Pioneering Digital Pathology

February 27, 2023

3 min read

Getting the right slide to the right pathologist at the right time – no matter where

False

The Pathologist
Subscribe

About

  • About Us
  • Work at Conexiant Europe
  • Terms and Conditions
  • Privacy Policy
  • Advertise With Us
  • Contact Us

Copyright © 2025 Texere Publishing Limited (trading as Conexiant), with registered number 08113419 whose registered office is at Booths No. 1, Booths Park, Chelford Road, Knutsford, England, WA16 8GS.