A Thorough NUDT15 Variant Catalogue
Scientists have catalogued almost every variant of the NUDT15 gene to understand its pharmacogenetic effects
Michael Schubert | | Quick Read
Thiopurine drugs serve a wide variety of purposes – from treating childhood leukemias to managing autoimmune disorders. However, not all patients tolerate thiopurines equally well. Until recently, doctors couldn’t predict how individual patients might react to treatment – but a research group at St. Jude Children’s Research Hospital in Memphis, Tennessee, recently catalogued almost every variant in the NUDT15 enzyme to better understand the potential for side effects (1). Senior author Jun Yang tells us more…
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