Subscribe to Newsletter
Diagnostics COVID-19, Microscopy and imaging, Microbiology and immunology

3D Imaging of the SARS-CoV-2 Replication Cycle

Credit: Julian Hennies/EMBL. Segmented subvolume of a cell, showing membrane-bound organelles (grey) and double-membrane vesicles (red).

As the COVID-19 pandemic continues, so too do global efforts to learn more about the virus. Researchers at Heidelberg University investigated how SARS-CoV-2 interacts with its host, replicates within the cell, and leads to cell death (1). They used focused ion beam scanning electron microscopy to image infected cells at the subcellular level in 3D – identifying structural changes caused by the virus.

They found significant remodeling of the endomembrane system of infected cells – a structure that defines different compartments within the cell. This change enables the virus to produce its own replication organelles, with the viral genome then replicating in large amounts in double-membrane vesicles (shown in red above).

Receive content, products, events as well as relevant industry updates from The Pathologist and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

  1. M Cortese et al., Cell Host Microbe, Online ahead of print (2020). PMID: 33245857.
Register to The Pathologist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Pathologist magazine