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Visualizing the Cancer Transcriptome

How RNA in situ Hybridization Offers an Essential Data Dimension in Cancer Research

Summary

Cancer is a disease of aberrant gene expression, and delineating the critical gene expression events during cancer development and progression is vital for cancer research. Here we summarize the role of novel RNA in situ hybridization technology in expanding the tool set available to researchers, thereby overcoming the challenges of cancer research in four key areas:

  1. Understanding tumor heterogeneity in gene expression
  2. Studying non-coding transcripts
  3. Developing biomarkers
  4. Driving and refining the diagnostic strategies of the future
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