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Routine integration of fully automated image analysis of Kreatech CLL FISH Probes, using the CytoVision GSL Scanning System

(Fully automated FISH Analysis for B-cell Chronic Lymphocytic Leukemia: a faster alternative to manual double scoring)

Executive Summary

The automation of FISH slide scoring in a high throughput fashion has long been a goal for cytogenetic analysis. The development of CytoVision automated scanning and image analysis has enabled realization of this aspiration. In the current study, automation was utilized across seven assays, in combination with a CLL menu of Kreatech FISH probes. The results demonstrate that the combination of Kreatech FISH probes with a fully automated, unsupervised analysis can successfully be used to classify patient samples according to known CLL-associated genomic abnormalities. The overall comparative analysis per CLL probe set, between manually scored slides and slides analyzed using automation and unsupervised analysis, showed at least 94% concordance, which increased to 100% following subsequent review. Overall, the hands-on time was drastically reduced by 88% (48 hr 45 min) and a permanent record for each sample automatically created. The full automation of the image analysis process using the CytoVision GSL-120 scanning system demonstrates the versatility and effectiveness of the system to be easily integrated into high throughput, routine FISH analysis.

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