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Inside the Lab Biochemistry and molecular biology, Digital and computational pathology, Bioinformatics

Biomarker Optimization on LabSat® Research

Biomarker discovery research in the field of immuno-oncology relies heavily on immunohistochemistry (IHC) assays, involving the execution of tailored protocols with a high number of steps, all of which are subject to optimization. This can be a lengthy process that can take days, weeks and even months to perform, and  requires  a  step-by-step  approach  to  finetune  protocol conditions such as assay temperature, antibody concentration or incubation times, in order to achieve optimal results with minimal investment of resources. Turnaround times of manual assays, even for single marker stainings, often require overnight incubations, and  existing  automated  staining  platforms,  while  faster,  still require several hours to stain one marker and can appear to be very expensive when performed for high throughput, which turns these optimization phases into a long burdensome processes.

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