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Deep Proteomic Profiling of Subregions within the Tumor Microenvironment Using MALDI Guided SpatialOMx®

Abstract

The timsTOF fleX system bridges a current gap by providing MALDI Imaging and in-depth proteomics analysis in just one instrument. The instrument offers all benefits of a timsTOF Pro for timeefficient and sensitive proteomics, combined with a high-resolution MALDI source and stage. Using PASEF technology, it is possible to retrieve high protein ID rates with small sample amounts. Here we present the new SpatialOMx workflow to identify distinct proteomic profiles for different tumor subpopulations in breast cancer as an example for this powerful approach.

Introduction

Since tissue and disease are correlated, SpatialOMx provides the unique opportunity to combine regiospecific information from MALDI Imaging with deep proteomic coverage for biomarker discovery and molecular characterization. MALDI Imaging has

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