Single Nucleotide Polymorphism Detection with the iPLEX® Assay and the MassARRAY® System

Introduction

The MassARRAY^® System from Agena Bioscience™ is a scalable platform with a suite of research applications for quantitative and qualitative nucleic acid analysis, enabling flexible assay design and fast time-to-results (Figure 1). Capable of easily interrogating from 10 to as many as 400 single nucleotide polymorphisms (SNPs) per sample, and analyzing from just a few samples to hundreds of samples per day, the MassARRAY System can be used on its own or in conjunction with nextgeneration sequencing (NGS) platforms to dramatically accelerate genetic analysis.

Figure 1: The MassARRAY System includes the MassARRAY Analyzer mass spectrometer and integrated data analysis software.

Since its introduction in 2000, the MassARRAY System has been widely adopted for a variety of genomic applications including gene fine-mapping, validation of genome-wide association studies, linkage studies, and routine genetic analysis of SNPs and somatic mutations. A variety of biomarkers can be analyzed from a full spectrum of biological samples including blood, plasma, buccal swabs, and even compromised formalin-fixed, paraffin-embedded (FFPE) samples, with as little as 5 ng input DNA.

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