A recent study published in the Journal of Clinical Pathology examined the prognostic roles of p21 and epidermal growth factor receptor (EGFR) expressions in colorectal cancer (CRC) among 12,319 patients in China. The research demonstrated that high p21 expression correlates with longer overall survival, while elevated EGFR levels predict poorer outcomes. Utilizing immunohistochemistry and statistical analyses, significant associations were found between biomarker expressions and clinicopathological features such as tumor stage and invasiveness, emphasizing their potential as prognostic indicators.
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